Product Specification:
| Alternative Name: | MORT1, Fas (TNFRSF6)-associated via death domain |
| Clone: | 1F7 |
| Host: | Mouse |
| Isotype: | IgG1 |
| Immunogen: | Recombinant human FADD. |
| UniProt ID: | Q13158 |
| Species reactivity: | Human, Mouse |
| Applications: | WB |
| Recommended Dilutions/Conditions: | Western Blot (1µg/ml, ECL)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. |
| Application Notes: | Detects a band of ~28kDa by Western blot. |
| Purity Detail: | Protein A affinity purified. |
| Formulation: | Liquid. In PBS containing 50% glycerol. |
| Shipping: | Shipped on Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | Fas-associating death domain containing protein (FADD)/MORT1 serves as a signal transducer of Fas-induced apoptosis. Through its amino-terminal death effector domain (DED), FADD binds to cytosolic proteins such as TRADD, a cytosolic death domaincontaining protein that asssociates with the cytosolic portion of TNF receptor, or MACH/FLICE/caspase-8, a protease with sequence homology to ICE-CED-3 protease family, in order to transduce the death signal. |
