Product Specification:
| Clone: | Agr-33 |
| Host: | Mouse |
| Isotype: | IgG1 |
| Immunogen: | Recombinant rat agrin (C-terminal fragment). |
| UniProt ID: | P25304 |
| GenBank ID: | M64780 |
| Species reactivity: | Mouse, Rat |
| Applications: | ICC, IHC, WB |
| Recommended Dilutions/Conditions: | Immunohistochemistry (10µg/ml)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. |
| Purity Detail: | Protein G affinity purified. |
| Formulation: | Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide. |
| Shipping: | Shipped on Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | Agrin is an essential extracellular matrix component which promotes clustering of nicotinic acetylcholine receptors (nAChRs) and other proteins at the neuromuscular junction during development. Agrin, MuSK, and Rapsyn are all essential components for AChR aggregation, through an unknown mechanism. The C-terminal region of agrin is released into the medium, interacts with receptors on the muscle surface and induces AChR aggregation. |
